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Cover photograph (Copyright © 2006, American Society for Microbiology. All Rights Reserved.): A protease-resistant globular domain makes up the heads of spikes that project from rotavirus virions. In crystals of this domain from rotavirus strain DS-1, each molecule “bites the tail” of its neighbor. The tail-biting cleft provides a potential ligand-binding site. (See related article on page 1513.)


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