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Journal of Virology, April 2000, p. 3413-3417, Vol. 74, No. 7
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Characterization of the P Protein-Binding Domain on the 10-Kilodalton Protein of Borna Disease Virus

Tahir H. Malik,1 Masahiko Kishi,2 and Patrick K. Lai1,*

Department of Biosciences, Salem-Teikyo University, Salem, West Virginia 26426-0500,1 and Central Laboratories, Kyoritsu Shoji Corporation, Kukizaki-machi, Inashiki-gun, Ibaraki 300-1252, Japan2

Received 18 October 1999/Accepted 30 December 1999

The Borna disease virus (BDV) is the prototype member of the Bornaviridae, and it replicates in the cell nucleus. The BDV p24P and p40N proteins carry nuclear localization signals (NLS) and are found in the nuclei of infected cells. The BDV p10 protein does not have an NLS, but it binds with P and/or N and is translocated to the nucleus. Hence, p10 may play a role in the replication of BDV in the cell nucleus. Here, we show that the P-binding domain is located in the N terminus of p10 and that S3 and L16 are important for the interaction.

* Corresponding author. Mailing address: Department of Biosciences, 239 Carlson Hall of Sciences, Salem-Teikyo University, Salem, WV 26426-0500. Phone: (304) 782-5575. Fax: (304) 782-5579. E-mail: lai{at}stunix.salem-teikyo.wvnet.edu.

Journal of Virology, April 2000, p. 3413-3417, Vol. 74, No. 7
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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