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Journal of Virology, September 2000, p. 8207-8212, Vol. 74, No. 17
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Transfer of Specificity for Human Immunodeficiency Virus Type 1 into Primary Human T Lymphocytes by Introduction of T-Cell Receptor Genes

Laurence J. N. Cooper,1,2,* Michael Kalos,1,dagger Deborah A. Lewinsohn,1,Dagger Stanley R. Riddell,1,3 and Philip D. Greenberg1,3

Program in Immunology, Fred Hutchinson Cancer Research Center,1 and Department of Pediatric Hematology and Oncology2 and Departments of Immunology and Medicine,3 University of Washington, Seattle, Washington

Received 22 February 2000/Accepted 7 June 2000

The introduction of genes encoding T-cell receptor (TCR) chains specific for human immunodeficiency virus into T cells of infected patients represents a means to quantitatively and qualitatively improve immunity to the virus. Our results demonstrate that the high level of TCR expression required for physiologic functioning can be reproducibly achieved with retroviral vectors encoding full-length unmodified TCR chains under the control of a strong internal constitutive phosphoglycerate kinase promoter.

* Corresponding author. Mailing address: Fred Hutchinson Cancer Research Center, D3-100, 1100 Fairview Ave. North, P.O. Box 19024, Seattle, WA 98109-1024. Phone: (206) 667-3428. Fax: (206) 667-7983. E-mail: lcooper{at}fhcrc.org.

dagger Present address: Corixa Corporation, Seattle, WA 98104.

Dagger Present address: Department of Pediatrics, Oregon Health Sciences University, Portland, OR 97201.

Journal of Virology, September 2000, p. 8207-8212, Vol. 74, No. 17
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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