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J. Virol., 01 1998, 415-419, Vol 72, No. 1
JM Bergelson, A Krithivas, L Celi, G Droguett, MS Horwitz, T Wickham, RL Crowell and RW Finberg
Complementary DNA clones encoding the murine homolog (mCAR) of the human
coxsackievirus and adenovirus receptor (CAR) were isolated. Nonpermissive
CHO cells transfected with mCAR cDNA became susceptible to infection by
coxsackieviruses B3 and B4 and showed increased susceptibility to
adenovirus-mediated gene transfer. These results indicate that the same
receptor is responsible for virus interactions with both murine and human
cells. Analysis of receptor expression in human and murine tissues should
be useful in defining factors governing virus tropism in vivo.
Copyright © 1998, American Society for Microbiology
The murine CAR homolog is a receptor for coxsackie B viruses and adenoviruses
Division of Infectious Diseases, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA. bergelson@email.chop.edu
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