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Journal of Virology, October 2008, p. 10318-10320, Vol. 82, No. 20
0022-538X/08/$08.00+0     doi:10.1128/JVI.00710-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Scrapie Resistance in ARQ Sheep{triangledown}

W. W. Laegreid,1* M. L. Clawson,2 M. P. Heaton,2 B. T. Green,3 K. I. O'Rourke,4 and D. P. Knowles4

Department of Pathobiology, University of Illinois, Urbana, Illinois 61802,1 Animal Health Research Unit, U.S. Meat Animal Research Center, USDA-ARS, Clay Center, Nebraska 68933,2 Poisonous Plant Research Laboratory, USDA-ARS, Logan, Utah 84341,3 Animal Disease Research Unit, USDA-ARS, Pullman, Washington 991634

Received 31 March 2008/ Accepted 8 July 2008

Variation in the ovine prion protein amino acid sequence influences scrapie progression, with sheep homozygous for A136R154Q171 considered susceptible. This study examined the association of survival time of scrapie-exposed ARQ sheep with variation elsewhere in the ovine prion gene. Four single nucleotide polymorphism alleles were associated with prolonged survival. One nonsynonymous allele (T112) was associated with an additional 687 days of survival for scrapie-exposed sheep compared to M112 sheep (odds ratio, 42.5; P = 0.00014). The only two sheep homozygous for T112 (TARQ) did not develop scrapie, suggesting that the allelic effect may be additive. These results provide evidence that TARQ sheep are genetically resistant to development of classical scrapie.

* Corresponding author. Mailing address: University of Illinois, Department of Pathobiology, 2001 S. Lincoln Ave., Urbana, IL 61802. Phone: (217) 244-8524. Fax: (217) 244-7421. E-mail: laegreid{at}uiuc.edu

{triangledown} Published ahead of print on 16 July 2007.

Journal of Virology, October 2008, p. 10318-10320, Vol. 82, No. 20
0022-538X/08/$08.00+0     doi:10.1128/JVI.00710-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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