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Journal of Virology, May 2005, p. 5833-5838, Vol. 79, No. 9
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.9.5833-5838.2005

Aged BALB/c Mice as a Model for Increased Severity of Severe Acute Respiratory Syndrome in Elderly Humans

Anjeanette Roberts,1* Christopher Paddock,2 Leatrice Vogel,1 Emily Butler,2 Sherif Zaki,2 and Kanta Subbarao1

Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, Maryland,1 Infectious Disease Pathology Activity, Centers for Disease Control and Prevention, Atlanta, Georgia2

Received 27 September 2004/ Accepted 15 December 2004

Advanced age has repeatedly been identified as an independent correlate of adverse outcome and a predictor of mortality in cases of severe acute respiratory syndrome (SARS). SARS-associated mortality may exceed 50% for persons aged 60 years or older. Heightened susceptibility of the elderly to severe SARS and the ability of SARS coronavirus to replicate in mice led us to examine whether aged mice might be susceptible to disease. We report here that viral replication in aged mice was associated with clinical illness and pneumonia, demonstrating an age-related susceptibility to SARS disease in animals that parallels the human experience.

* Corresponding author. Mailing address: LID, NIAID, NIH, 50 South Dr., Room 6351, MSC 8007, Bethesda, MD 20892. Phone: (301) 496-3490. Fax: (301) 496-8312. E-mail: ajroberts{at}niaid.nih.gov.

Journal of Virology, May 2005, p. 5833-5838, Vol. 79, No. 9
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.9.5833-5838.2005




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