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Journal of Virology, December 2005, p. 15578-15581, Vol. 79, No. 24
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.24.15578-15581.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Hepatitis C Virus (HCV) and Hepatitis B Virus (HBV) Can Coinfect the Same Hepatocyte in the Liver of Patients with Chronic HCV and Occult HBV Infection

E. Rodríguez-Íñigo,1 J. Bartolomé,1 N. Ortiz-Movilla,1 C. Platero,2 J. M. López-Alcorocho,1 M. Pardo,1 I. Castillo,1 and V. Carreño1*

Fundación para el Estudio de las Hepatitis Virales, Madrid, Spain,1 Departamento de Electrónica, Automática e Informática Industrial, Universidad Politécnica de Madrid, Madrid, Spain2

Received 11 July 2005/ Accepted 20 September 2005

In this work, we have shown that hepatitis C virus (HCV) and hepatitis B virus (HBV) can coexist in the same hepatocyte using double fluorescent in situ hybridization in liver biopsy samples from patients with chronic HCV infection with occult HBV infection. Digital image analysis of hybridization signals showed that the HBV DNA levels in coinfected hepatocytes were lower than those in cells infected only with HBV. This finding supports the hypothesis of inhibition of HBV replication by HCV. Furthermore, HCV RNA levels were lower in coinfected cells than in cells infected only with HCV, suggesting that HBV may also inhibit HCV replication.

* Corresponding author. Mailing address: Fundación para el Estudio de las Hepatitis Virales, C/ Guzmán El Bueno, 72, 28015 Madrid, Spain. Phone: 34 91 544 60 13. Fax: 34 91 544 92 28. E-mail: fehvhpa{at}fehv.org.

Journal of Virology, December 2005, p. 15578-15581, Vol. 79, No. 24
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.24.15578-15581.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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