This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Valas, S.
Right arrow Articles by Mamoun, R. Z.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Valas, S.
Right arrow Articles by Mamoun, R. Z.

 Previous Article  |  Next Article 

Journal of Virology, July 2000, p. 6178-6185, Vol. 74, No. 13
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Variability and Immunogenicity of Caprine Arthritis-Encephalitis Virus Surface Glycoprotein

S. Valas,1,* C. Benoit,1 C. Baudry,1 G. Perrin,1 and R. Z. Mamoun2

AFSSA-Niort, Laboratoire de Recherches Caprines, F-79012 Niort Cedex,1 and Laboratoire Rétrovirus et Thérapie, INSERM U443, Université Victor Segalen Bordeaux 2, F-33076 Bordeaux Cedex,2 France

Received 3 February 2000/Accepted 29 March 2000

The complete surface glycoprotein (SU) nucleotide sequences of three French isolates of caprine arthritis-encephalitis virus (CAEV) were determined and compared with those of previously described isolates: three American isolates and one French isolate. Phylogenetic analyses revealed the existence of four distinct and roughly equidistant evolutionary CAEV subtypes. Four conserved and five variable domains were identified in the SU. The fine specificities of antibodies produced against these domains during natural infection were examined using a pepscan analysis. Nine immunogenic segments were delineated throughout the conserved and variable domains of SU, two of them corresponding to conserved immunodominant epitopes. Antigenic determinants which may be involved in the immunopathogenic process induced by CAEV were identified. These results also provide sensitive and specific antigen peptides for the serological detection and differentiation of CAEV and visna/maedi virus infections.

* Corresponding author. Mailing address: AFSSA-Niort, Laboratoire de Recherches Caprines, B.P. 3081, 60 rue de Pied de Fond, F-79012 Niort Cedex, France. Phone: (33) 5 49 79 61 28. Fax: (33) 5 49 79 42 19. E-mail: s.valas{at}niort.afssa.fr.

Journal of Virology, July 2000, p. 6178-6185, Vol. 74, No. 13
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Haflidadottir, B. S., Matthiasdottir, S., Agnarsdottir, G., Torsteinsdottir, S., Petursson, G., Andresson, O. S., Andresdottir, V. (2008). Mutational analysis of a principal neutralization domain of visna/maedi virus envelope glycoprotein. J. Gen. Virol. 89: 716-721 [Abstract] [Full Text]  
  • Pisoni, G., Bertoni, G., Puricelli, M., Maccalli, M., Moroni, P. (2007). Demonstration of Coinfection with and Recombination by Caprine Arthritis-Encephalitis Virus and Maedi-Visna Virus in Naturally Infected Goats. J. Virol. 81: 4948-4955 [Abstract] [Full Text]  
  • Mordasini, F., Vogt, H.-R., Zahno, M.-L., Maeschli, A., Nenci, C., Zanoni, R., Peterhans, E., Bertoni, G. (2006). Analysis of the antibody response to an immunodominant epitope of the envelope glycoprotein of a lentivirus and its diagnostic potential.. J. Clin. Microbiol. 44: 981-991 [Abstract] [Full Text]  
  • Gjerset, B., Storset, A. K., Rimstad, E. (2006). Genetic diversity of small-ruminant lentiviruses: characterization of Norwegian isolates of Caprine arthritis encephalitis virus.. J. Gen. Virol. 87: 573-580 [Abstract] [Full Text]  
  • Herrmann, L. M., McGuire, T. C., Hotzel, I., Lewis, G. S., Knowles, D. P. (2005). Surface Envelope Glycoprotein Is B-Lymphocyte Immunodominant in Sheep Naturally Infected with Ovine Progressive Pneumonia Virus. CVI 12: 797-800 [Abstract] [Full Text]  
  • Trujillo, J. D., Kumpula-McWhirter, N. M., Hotzel, K. J., Gonzalez, M., Cheevers, W. P. (2004). Glycosylation of Immunodominant Linear Epitopes in the Carboxy-Terminal Region of the Caprine Arthritis-Encephalitis Virus Surface Envelope Enhances Vaccine-Induced Type-Specific and Cross-Reactive Neutralizing Antibody Responses. J. Virol. 78: 9190-9202 [Abstract] [Full Text]  
  • Hotzel, I., Cheevers, W. P. (2003). Caprine Arthritis-Encephalitis Virus Envelope Surface Glycoprotein Regions Interacting with the Transmembrane Glycoprotein: Structural and Functional Parallels with Human Immunodeficiency Virus Type 1 gp120. J. Virol. 77: 11578-11587 [Abstract] [Full Text]  
  • Andresdottir, V., Skraban, R., Matthiasdottir, S., Lutley, R., Agnarsdottir, G., Thorsteinsdottir, H. (2002). Selection of antigenic variants in maedi-visna virus infection. J. Gen. Virol. 83: 2543-2551 [Abstract] [Full Text]  
  • Grego, E., Profiti, M., Giammarioli, M., Giannino, L., Rutili, D., Woodall, C., Rosati, S. (2002). Genetic Heterogeneity of Small Ruminant Lentiviruses Involves Immunodominant Epitope of Capsid Antigen and Affects Sensitivity of Single-Strain-Based Immunoassay. CVI 9: 828-832 [Abstract] [Full Text]  
  • Hötzel, I., Cheevers, W. P. (2001). Conservation of Human Immunodeficiency Virus Type 1 gp120 Inner-Domain Sequences in Lentivirus and Type A and B Retrovirus Envelope Surface Glycoproteins. J. Virol. 75: 2014-2018 [Abstract] [Full Text]  
  • Ozyoruk, F., Cheevers, W. P., Hullinger, G. A., McGuire, T. C., Hutton, M., Knowles, D. P. (2001). Monoclonal Antibodies to Conformational Epitopes of the Surface Glycoprotein of Caprine Arthritis-Encephalitis Virus: Potential Application to Competitive-Inhibition Enzyme-Linked Immunosorbent Assay for Detecting Antibodies in Goat Sera. CVI 8: 44-51 [Abstract] [Full Text]  
  • Bertoni, G., Hertig, C., Zahno, M.-L., Vogt, H.-R., Dufour, S., Cordano, P., Peterhans, E., Cheevers, W. P., Sonigo, P., Pancino, G. (2000). B-cell epitopes of the envelope glycoprotein of caprine arthritis-encephalitis virus and antibody response in infected goats. J. Gen. Virol. 81: 2929-2940 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»