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J Virol, March 1998, p. 1790-1796, Vol. 72, No. 3
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Effect of Passive Immunization or Maternally Transferred Immunity on the Antibody Response to a Genetic Vaccine to Rabies Virus

Yijie Wang,dagger Zhiquan Xiang, Susanna Pasquini, and Hildegund C. J. Ertl*

The Wistar Institute, Philadelphia, Pennsylvania

Received 24 October 1997/Accepted 24 November 1997

A plasmid vector, termed pSG5rab.gp, expressing the glycoprotein of rabies virus was tested in young adult or neonatal mice in the presence of maternally transferred immunity or passively administered antibodies to rabies virus for induction of an antibody response. Mice born to rabies virus-immune dams developed an impaired antibody response to genetic immunization at 6 weeks of age, as had been previously observed upon vaccination with an inactivated viral vaccine. Similarly, mice passively immunized with hyperimmune serum showed an inhibited B-cell response upon vaccination with the pSG5rab.gp vector, resulting in both cases in vaccine failures upon challenge with a virulent strain of rabies virus. In contrast, the immune responses of mice vaccinated as neonates in the presence of maternal immunity or upon passive immunization to rabies virus with the pSG5rab.gp construct were only marginally affected.

* Corresponding author. Mailing address: The Wistar Institute, 3601 Spruce St., Philadelphia, PA 19104-4268. Phone: (215) 898-3863. Fax: (215) 898-3953. E-mail: Ertl{at}wista.wistar.upenn.edu

dagger Present address: NYU Medical Center, Skirball Institute, New York, NY 10016.




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